Should You Network Activate All Plugins on WordPress Multisite

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Plugin supports only network-wide activation. It’s better to activate it and setup the all the constants in wp-config.php file – they will be applied to all subsite in your network. Individual subsites will be able to change From Name/Email if you don’t use them in constants.
Everything You Need to Know to Activate and Use WordPress Multisite
Multisite is a feature that’s already built into WordPress, but disabled by default. This means that you simply need to enable it, which you can do for both existing and new sites. However, it’s often best to create an entirely new setup instead of using an existing website. The process works much the same in both cases, but the former option enables you to choose between using subdomains or subdirectories for your individual sites. We’ll talk more about that in a minute. For now, however, let’s focus on what you’ll need to get started.
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How to Set Up WordPress Multisite Network
Hi David! I saw that you got your answer over at the WordPress.org support forums. But to answer your question here, Multisite doesn’t allow embeds for users other than super admins for security reasons, as embeds can allow for malicious code to be injected into your site. However, there is a way around this! There’s an internal whitelist built into WordPress that allows YouTube and Vimeo videos to be embedded. You can read more about it in the WordPress Codex: https://codex.wordpress.org/Embeds
WordPress Multisite: Setting up, configuring, and managing the network
This type of setup is also helpful in larger organizations that might need different designs and managers for different groups or departments. A perfect example might be a single college that has unique “schools” (Edublogs — the world’s second largest Multisite behind WordPress.com — springs to mind here), or if you’re creating different websites for international visitors’ native language.
WordPress.org
Hello, For MultiSite, you should not activate the plugin through SuperAdmin dashboard, but within individual sites. If you can’t de-activate the plugin in a subsite, it means it’s been activated on SuperAdmin, which is not correct.
WordPress.org
So if you have any of the above defines in your wp-config.php. Or you have database tables named {prefix}{number}{table} where {prefix} is the same as you defined in your wp-config.php (or {number} is part of the prefix), and {number} is a number following an underscore, causing tables to be named similar to wp_1_posts. In that case WordPress might think your website is a multisite installation.
How to install and set up a WordPress Multisite
Install or uninstall plugins or themes in a WordPress multisite network is something only the super admin can do. The site admins within the network can only activate or deactivate them. Well, and site admins can only activate and deactivate plugins in case the super admin checked the box Enable administration menus in the network administration in Settings → Network Settings.
Complete Guide: How to Install and Setup a WordPress Multisite Network
One important detail at the bottom of the page is the Enable Administration menus option. If you check Plugins, individual site admins will be able to manually enable or disable plugins. They will NOT be able to add new plugins, though. They can only choose from the plugins you activate network wide in the Plugins tab of your Network Admin Dashboard.
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I network activated this on some of our multisites. Hasn’t broken anything yet but the real test will be when 5.0 stable is released. We’re just now playing with the 5.0 RC to see if we run into any compatibility issues, hard to tell with all the bugs it currently has.
WordPress.org
Plugin management for WordPress Multisite that supports the native plugins page and the WPMU DEV Pro Sites plugin! Used on thousands of multisite installs across the web. Previously known as WPMU Plugin Manager, it uses a backend options page to adjust plugin permissions for all the sites in your network.